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KMID : 1161420160190010106
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Journal of Medicinal Food
2016 Volume.19 No. 1 p.106 ~ p.109
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Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization
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Yang Sung-Jae
Jo Hyoung
Kim Kyung-A
Ahn Hong-Ryul
Kang Suk-Woo
Jung Sang-Hoon
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Abstract
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The purpose of this study was to evaluate the effect of ethanol extract of Diospyros kaki (EEDK) leaves on corneal neovascularization (CoNV) in rats. One week after the alkali burns in the corneas, the CoNV area coverage in the CoNV-positive control group, 100?mg/kg EEDK group, and 200?mg/kg EEDK group was 43.3%?±?5.5%, 337.7%?±?2.5%, and 27.2%?±?4.3%, respectively. The areas of CoNV in the EEDK-treated groups were significantly different from those of the CoNV group. EEDK significantly attenuated the upregulation of vascular endothelial growth factor, fibroblast growth factor, interleukin-6, and matrix metalloproteinase-2 (MMP-2) protein levels. Orally administrated D. kaki inhibited CoNV development in rats.
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KEYWORD
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alkali burn, angiogenic factors, corneal neovascularization, Diospyros kaki, eye diseases
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